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Prediction published on Sep 17, 2025 10:28 AM by Dario in Europe - Champions League | Modified on Sep 17, 2025 10:31 AM
The UEFA Champions League group stage kicks off with a fascinating clash at the Johan Cruijff ArenA, where Ajax will host Inter Milan. Both sides enter this encounter with contrasting domestic form but share the same ambition of starting their European campaign on the right foot. Ajax are returning to the competition after a two-year absence, while Inter arrive as last season’s runners-up, eager to bounce back from their heavy defeat in the final. With both teams boasting attacking firepower but also showing defensive vulnerabilities, this promises to be one of the standout fixtures of matchday one.
Ajax secured their Champions League spot after finishing second in the Eredivisie last season, and they have started the current campaign strongly. In their last five matches, they remain unbeaten with three wins and two draws, averaging 2.0 goals scored and 0.8 conceded per game. Their most recent outing was a convincing 3-1 home victory against PEC Zwolle on September 13, which further boosted confidence ahead of this European test.
The Amsterdammers have been particularly reliable in front of goal. They have scored in each of their last five matches, and remarkably, over 0.5 goals have been scored in their last 40 fixtures across all competitions. At home, their attacking consistency is even more evident, with over 1.5 goals scored in each of their last 21 home games. They also tend to start strongly, having led at half-time in their last four home matches.
However, Ajax’s record against Italian opposition is less encouraging. They are currently on a seven-match winless run against Serie A sides in European competitions, and historically, they have struggled against Inter, failing to win in four previous meetings. Injuries could also play a role, with Steven Berghuis, Aaron Bouwman, and long-term absentee Branco van den Boomen sidelined. Coach John Heitinga is expected to stick with a 4-3-3 formation, with Wout Weghorst leading the line after scoring three goals in the Eredivisie so far.
Inter Milan enter this clash with mixed emotions. On one hand, they reached the Champions League final last season, going on an impressive eight-match unbeaten run before their heavy 5-0 defeat to Paris Saint-Germain. On the other hand, their domestic form has been inconsistent. After a flying start with a 5-0 win over Torino in Serie A, they have since suffered back-to-back defeats, including a 4-3 loss to Juventus on September 13.
Despite these setbacks, Inter remain a dangerous side in Europe. They have lost only twice in their last 15 Champions League matches and have not trailed at half-time in 20 of their last 22 UCL fixtures. Their attack is spearheaded by Marcus Thuram, who has already been involved in four goal contributions this season and leads Serie A with three goals. However, the absence of Lautaro Martinez due to injury is a significant blow. Youngster Francesco Pio Esposito is expected to partner Thuram in attack, while the back three of Bastoni, Acerbi, and Akanji will aim to provide defensive stability.
Inter’s recent matches have been high-scoring, with over 1.5 goals in each of their last 12 games and an average of 2.2 goals scored and 2.2 conceded across their last five fixtures. This trend suggests that goals are likely when they take the field, especially against an Ajax side that rarely fails to score at home.
This fixture brings together two teams with strong attacking records but defensive weaknesses. Ajax’s home advantage and current unbeaten streak in the Eredivisie give them confidence, while Inter’s European pedigree and attacking duo of Thuram and Esposito make them a constant threat. The Dutch side will look to exploit Inter’s recent defensive lapses, having conceded six goals in their last two matches, while Inter will rely on their experience and ability to perform on the big stage.
Historically, Inter have had the upper hand in this matchup, with three wins and one draw in their four previous meetings. However, Ajax’s attacking form and Inter’s recent defensive struggles suggest that both teams are likely to find the net. With both sides averaging over two goals scored per game in recent weeks, a high-scoring contest is on the cards.
Ajax vs Inter Milan prediction from BetMines: Both Teams To Score (Yes) with 56% probability.
This section provides average statistics and percentages on the main markets for the last 10 matches of both teams
Ajax
Inter
Under
Over
Under
Over
0.5
1
9
0
10
1.5
2
8
0
10
2.5
4
6
4
6
3.5
7
3
6
4
4.5
10
0
7
3