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Prediction published on Sep 28, 2025 11:07 AM by Dario in Europe - Champions League | Modified on Sep 30, 2025 12:30 PM
After a 2-0 away victory over Ajax in their opening match, Cristian Chivu's Inter has a great opportunity to reach six points in the standings, hosting Slavia Prague in Milan for Matchday 2 of the UEFA Champions League. The home side’s objective is clear: secure maximum points in the next three matches against Slavia Prague, Royale Union SG, and Kairat Almaty—teams that, on paper, are more manageable—before facing Atletico Madrid, Liverpool, and Arsenal, while still keeping strong chances of direct qualification to the Round of 16. Slavia Prague, coming off a 2-2 home draw against Bodo/Glimt, knows how tough it is to face the Nerazzurri at San Siro, but they are motivated not to play the role of the sacrificial victim. Trpišovský’s men are aware that their schedule allows no respite: besides Inter, they will face Arsenal, Athletic Bilbao, Tottenham, and Barcelona. To keep hopes alive of finishing at least in the top 24, thus securing a place in the knockout round playoffs, it is crucial to get a positive result at San Siro—a mission that is far from easy.
After a few difficult weeks between late August and mid-September, Cristian Chivu’s Inter has regained confidence, stringing together three consecutive wins in the Champions League and Serie A. Their latest victory, which brought the Nerazzurri to 9 points in Serie A (3 wins, 2 losses), came on September 27: a 2-0 win at Cagliari, with goals from Lautaro Martinez and Francesco Pio Esposito.
In the last five matches, the Italian and European runners-up recorded 3 wins and 2 losses, with an average of 2 goals scored and 1.4 conceded per game. Defensively, the good news is that in the last three matches against Ajax, Sassuolo, and Cagliari, they conceded just one goal, showing signs of recovery. Offensively, the left flank is particularly exploited, with Dimarco and Bastoni frequently supplying attackers with precise crosses and assists.
Playing at home is a huge advantage for Inter: at San Siro, the Nerazzurri are unbeaten in this competition in 16 consecutive games. More generally, Lautaro and his teammates have won or drawn 9 of their last 10 matches in Europe’s top competition, losing only to Paris Saint-Germain in the Munich final.
Slavia Prague arrives in Milan full of confidence, remaining unbeaten in 13 matches across the league, national cup, and Champions League. On Friday, September 26, Trpišovský’s men won the derby 2-0 against Dukla Prague, climbing to second place in the Czech First League with 24 points (7 wins, 3 draws) after 10 matchdays.
In their last five official matches, the Red-Whites recorded 3 wins and 2 draws, averaging 2 goals scored and 0.8 conceded per game. These stats reflect a team that is prolific in attack but also solid in defense, as shown by the zero goals conceded in the last two matches against Brozany and Dukla Prague. The main offensive threat comes from Tomas Chory, who has scored 3 goals in 5 appearances this season.
The Czechs also have a strong away record, being unbeaten in six consecutive matches outside their home ground with 4 wins and 2 draws. Furthermore, Slavia Prague has scored at least one goal in each of their last ten away matches.
Inter is clearly the favorite in this Champions League group stage clash against Slavia Prague, aiming to secure three crucial points to move closer to direct qualification for the Round of 16.
The Nerazzurri can count on the home advantage and, above all, on a squad that is significantly stronger than their opponents, factors that suggest a fairly convincing win. Recent head-to-head encounters confirm this trend: in the 2019/20 season, the two teams faced each other twice, with a 3-1 win for Inter and a 1-1 draw.
Tactically, BetMines’ algorithm predicts that the home side will maintain possession for longer, exploiting the midfield wings, Dimarco and Dumfries, and feeding through balls to Thuram, who was decisive with a double against Ajax in the opener.
Slavia Prague, on the other hand, will likely be forced to withstand Inter’s pressure, and as the minutes pass, it is highly probable that the Czech defensive wall will eventually break.
The visitors also face difficulties in attack: it appears challenging for Trpišovský’s men to create real threats for Sommer, considering the current good form of Inter’s backline.
INTER (3-5-2): Martinez; Akanji, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Sucic, Dimarco; Martinez, Thuram. Coach: Chivu.
SLAVIA PRAGUE (4-2-3-1): Markovic; Doudera, Chaloupek, Zima, Mbodji; Zafeiris, Dorley; Kusej, Cham, Provod; Chory. Coach: Trpišovský.
This section provides average statistics and percentages on the main markets for the last 10 matches of both teams
Inter
Slavia Praha
Under
Over
Under
Over
0.5
0
10
2
8
1.5
0
10
2
8
2.5
4
6
3
7
3.5
6
4
6
4
4.5
7
3
9
1