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Napoli
0 - 0
FT
Eintracht Frankfurt
Prediction published on Nov 2, 2025 2:42 PM by Dario in Europe - Champions League | Modified on Nov 2, 2025 6:13 PM
On Tuesday, November 4, at the Diego Armando Maradona Stadium, the Matchday 4 clash of the UEFA Champions League takes place between Napoli and Eintracht Frankfurt — two teams fighting for crucial points to keep their hopes of advancing to the knockout stage alive. After the first three matchdays, both sides sit level on 3 points, with the Germans slightly ahead due to a better goal difference. The hosts, currently competing for the Serie A title, need a win not only to climb up the table but also to bounce back from the heavy 6-2 defeat suffered on October 21 against PSV. The visitors, sixth in the Bundesliga, come into this match after two European defeats by 5-1, against Atletico Madrid and Liverpool, and are looking for their first win since the opening match against Galatasaray. As we reach the halfway point of the group stage, this game could reveal a lot about both teams’ true European ambitions, with both seeking redemption after recent setbacks against PSV and Liverpool.
Napoli come into this match on the back of three positive results (2 wins, 1 draw) but want to make amends after the disappointing 0-0 home draw against Como on November 1. Over their last five games in all competitions, the Azzurri have recorded 2 wins, 1 draw, and 2 defeats, averaging 1.2 goals scored and 1.6 conceded per match.
After three rounds of the Champions League, Conte’s men sit 23rd overall with just 3 points — the result of a 2-1 win over Sporting Lisbon and two away defeats to Manchester City (2-0) and PSV (6-2). They’ve averaged 1.33 goals scored and 3 conceded per game so far.
Napoli boast an impressive home record, remaining unbeaten in their last 17 matches at the Diego Armando Maradona Stadium. Narrowing it down to the Champions League, the reigning Italian champions have won or drawn 10 of their last 11 home games in the competition.
It’s not an easy moment for Eintracht Frankfurt, who were recently eliminated from the DFB-Pokal by Borussia Dortmund and drew 1-1 away at Heidenheim in their latest Bundesliga match. In their last five official games, the Germans have recorded 1 win, 3 draws, and 1 defeat, with an average of 1.4 goals scored and 1.8 conceded.
Their European campaign has mirrored Napoli’s so far, with 3 points gained thanks to their opening 5-1 win over Galatasaray, followed by two heavy defeats to Atletico Madrid (5-1) and Liverpool (1-5). Alongside Ajax, Eintracht have conceded the most goals in the UCL this season, averaging 3.66 goals allowed per match. This run places them 22nd overall in the group stage standings.
Toppmöller’s side are winless in their last three away matches — a loss against Atletico Madrid in the Champions League and two league draws against Freiburg and Heidenheim. In their last six away games in all competitions, they have both scored and conceded in every match.
The BetMines prediction for Napoli vs Eintracht Frankfurt leans in favor of the home team, who are determined to capitalize on this home fixture to climb back into the top 24 positions and stay on track for qualification to the Round of 32.
The last time these two teams met was in the Round of 16 of the 2022/2023 Champions League, when Napoli won both legs — 0-2 away and 3-0 at home. The Azzurri therefore also have the recent head-to-head record on their side.
Given that both teams have conceded heavily in this season’s UCL, BetMines expects an open and entertaining match with plenty of goal-scoring opportunities. The algorithm suggests two valuable betting tips: Over 2.5 goals (57% probability) and “Both Teams to Score - Yes” (56% probability).
As for team news, Antonio Conte will once again be without key players such as De Bruyne, Meret, and Lukaku, as well as the suspended Lucca. For the visitors, Oscar Højlund, Baum, and Ngankam are ruled out, while Uzun — who has already scored nine goals this season — remains a doubt.
NAPOLI (4-3-3): Milinkovic-Savic; Di Lorenzo, Rrahmani, Buongiorno, Spinazzola; Anguissa, Lobotka, McTominay; Politano, Hojlund, Neres. Coach: Conte
EINTRACHT FRANKFURT (3-4-2-1): Zetterer; Kristensen, Koch, Theate; Doan, Larsson, Chaibi, Brown; Gotze, Knauff; Burkardt. Coach: Toppmöller
This section provides average statistics and percentages on the main markets for the last 10 matches of both teams
Napoli
Eintracht Frankfurt
Under
Over
Under
Over
0.5
1
9
1
9
1.5
3
7
2
8
2.5
5
5
4
6
3.5
8
2
7
3
4.5
9
1
9
1