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Prediction published on Oct 2, 2025 10:24 AM by Dario in Italy - Serie A | Modified on Oct 4, 2025 10:34 AM
On Sunday, October 5, at the Stadio Diego Armando Maradona, Napoli and Genoa face off in the penultimate match of Serie A Matchday 6, just before the international break. The hosts have experienced a rollercoaster week: first losing in the league against AC Milan, then bouncing back with a Champions League victory over Sporting Lisbon. Antonio Conte’s team, currently top of the table alongside Roma and AC Milan, are looking to extend their positive run. The clash against Genoa is a huge opportunity to secure first place, with hopes that the Rossoneri and the Giallorossi, playing Juventus and Fiorentina, might drop points this weekend. The goal is to reach the break as league leaders, approaching the upcoming fixtures — including the big match against Inter Milan on October 25 — with strong momentum. Genoa, on the other hand, are still searching for their first win of the season. So far, they have only collected two draws and three defeats. Their only joys have come in the Coppa Italia, but that is not enough to improve their disappointing start. While the challenge in Naples looks daunting, the Rossoblù will have to dig deep to return home with three points, hoping to relaunch their survival hopes and move away from the bottom of the table.
Napoli are coming from an inconsistent run, with two wins and two defeats in their last four matches across Serie A and the Champions League. Last week, they lost 2-1 in the big league clash against AC Milan but immediately bounced back in Europe, beating Sporting Lisbon 2-1 thanks to a Rasmus Højlund brace.
After five Serie A matchdays, Antonio Conte’s men have collected 12 points from 4 wins and 1 defeat. The Azzurri boast the second-best attack in the league with 10 goals scored (2 per game on average) and have conceded 5 goals (1 per match).
The Stadio Diego Armando Maradona remains a fortress: Napoli are unbeaten in 14 straight home matches and have lost only once in their last 13 Serie A home games. More broadly, the reigning Italian champions have picked up points in 27 of their last 28 matches across all competitions.
Genoa are going through a rough patch: last round they lost 3-0 at home to Lazio, suffering their second straight defeat after falling 2-1 away to Bologna. Their only positive result came in the Coppa Italia, where they beat Empoli 3-1 to advance to the Round of 16 against Atalanta.
Patrick Vieira’s side are still without a win in Serie A: their record so far is 2 draws and 3 defeats, with just 2 points on the board. The Rossoblù share the worst attack in the league with Verona and Torino, having scored only 2 goals (0.4 per game) and conceded 7 (1.4 per match).
Their away form isn’t encouraging either: in their two trips this season, they’ve collected one draw and one defeat (2 goals scored, 3 conceded). More generally, Genoa have won just 1 of their last 13 Serie A away games, with 6 draws and 6 defeats.
The Serie A Matchday 6 clash between Napoli and Genoa clearly favors the home side. According to BetMines’ algorithm, Napoli’s win (1) has a 69% probability, while a Rossoblù victory sits at just 11%.
Napoli, missing Buongiorno in defense, will rely on the creativity of Kevin De Bruyne to deliver through balls for Højlund and feed the runs of Scott McTominay. At the back, Beukema should replace young Marianucci, who was partly responsible for the goals conceded against AC Milan. This change could offer more solidity and increase Napoli’s chances of keeping a clean sheet.
Genoa, meanwhile, are unlikely to create many chances against Meret’s goal. Their attack continues to struggle without a reliable striker to hold up play: Lorenzo Colombo is still goalless in Serie A, while Malinovskyi and Vitinha — though talented — often lack sharpness in front of goal due to the defensive workload required by Vieira.
For these reasons, BetMines’ prediction leans heavily in favor of Napoli: not only are they strong favorites to win, but they also have a good chance of keeping a clean sheet.
NAPOLI (4-2-3-1): Meret; Di Lorenzo, Beukema, Juan Jesus, Guterriez; Lobotka, Anguissa; Politano, De Bruyne, McTominay; Højlund. Coach: Antonio Conte
GENOA (4-2-3-1): Leali; Norton-Cuffy, Østigård, Vásquez, Martín; Frendrup, Masini; Ellertsson, Malinovskyi, Vitinha; Colombo. Coach: Patrick Vieira
This section provides average statistics and percentages on the main markets for the last 10 matches of both teams
Napoli
Genoa
Under
Over
Under
Over
0.5
1
9
2
8
1.5
3
7
2
8
2.5
5
5
6
4
3.5
8
2
10
0
4.5
9
1
10
0